AMBISOME INJECTION 1 VIAL

Product Introduction:

Ambisome Injection is a brand name for Liposomal Amphotericin B, which is an antifungal medication used to treat severe fungal infections. The liposomal formulation of Amphotericin B enhances its delivery and reduces its toxicity compared to conventional formulations. It is commonly used to treat systemic fungal infections, particularly those caused by Candida species, Aspergillus species, and other fungi.

Ambisome Injection is generally administered by a doctor or a nurse. You should not self-administer this medicine at home. The dose and duration of the treatment will depend on the severity of your condition. You should get the injection as long as your doctor has prescribed it.

The most common side effects of this medicine are decreased potassium level in the blood, nausea, vomiting, chills, and fever. Consult your doctor if these side effects persist for a longer duration or get worse. They may be able to suggest ways to prevent or reduce the side effects.

To make sure it is safe for you, before using this medicine, let your doctor know if you have any preexisting medical conditions or if you are taking any other medicines. Let your doctor also know if you are pregnant or breastfeeding, as it may cause harmful effects to the developing baby.

Benefits:

1. Effective Treatment: Ambisome Injection is highly effective in treating severe fungal infections, including invasive candidiasis, invasive aspergillosis, cryptococcal meningitis, and mucormycosis.
2. Broad Spectrum Activity: It exhibits broad-spectrum activity against various fungal species, making it suitable for treating a wide range of fungal infections.
3. Reduced Toxicity: The liposomal formulation reduces the risk of nephrotoxicity (kidney damage) associated with conventional formulations of Amphotericin B, allowing for safer and more prolonged use.

Side Effects:

Common side effects of Ambisome Injection may include:

• Fever
• Chills
• Headache
• Nausea
• Vomiting
• Diarrhea
• Muscle or joint pain
• Injection site reactions

Less common but more serious side effects may include:

• Kidney damage (nephrotoxicity)
• Infusion-related reactions, including hypotension, flushing, and shortness of breath
• Electrolyte imbalances, such as hypokalemia or hypomagnesemia
• Liver toxicity
• Anemia
• Decreased levels of potassium or magnesium in the blood

Usage Guidelines:

• Ambisome Injection is administered intravenously by a healthcare professional in a hospital or clinical setting.
• The dosage and duration of treatment depend on the severity of the infection, the patient’s weight, and kidney function.
• It is important to follow the healthcare provider’s instructions carefully and complete the full course of treatment, even if symptoms improve before the treatment is completed.
• Patients may need regular monitoring of kidney function, electrolyte levels, and other parameters during treatment.

Drug Interactions:

• Ambisome Injection may interact with other medications, including:
  • Nephrotoxic drugs, such as aminoglycosides, cyclosporine, or tacrolimus
  • Diuretics
  • Antifungal medications
  • Antiviral medications
  • Immunomodulating agents
• Inform the healthcare provider about all medications, supplements, and herbal products being taken to avoid potential interactions.

Important Note:

Ambisome Injection should only be used under the supervision of a healthcare professional experienced in the management of fungal infections. It is essential to weigh the potential benefits against the risks of treatment, especially considering its potential for side effects and interactions. This information serves as a general guideline and should not replace professional medical advice.

SAFETY ADVICE

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Ambisome Injection. Please consult your doctor.

Pregnancy

SAFE IF PRESCRIBED

Ambisome Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Breast feeding

CONSULT YOUR DOCTOR

Ambisome Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

CONSULT YOUR DOCTOR

It is not known whether Ambisome Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney

SAFE IF PRESCRIBED

Ambisome Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Ambisome Injection may not be needed in these patients. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited information available on the use of Ambisome Injection in patients with liver disease. Please consult your doctor.