APLEVANT 1.5MG INJECTION 1 PACK

Product Introduction:

Aplevant 1.5mg injection contains dulaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist. It is prescribed to help manage blood sugar levels in adults with type 2 diabetes mellitus. Dulaglutide mimics the action of GLP-1, a hormone that stimulates insulin secretion and reduces glucagon production, thereby improving blood sugar control.

The dose of Aplevant 1.5mg injection(0.5ml Each) will depend on your condition and what other diabetes medicines you are taking. You can use it at any time of day with or without food but try to use it on the same day each week to get the most benefit. Your doctor or nurse will show you how and where to inject the medicine. Follow the instructions carefully. Do not stop taking this medicine without talking to your doctor. If you do, your blood glucose levels may increase and put you at risk of serious complications. It should be used with a proper diet and exercise to control high blood glucose.Aplevant 1.5mg injection (0.5ml Each) should be stored in a fridge until you need it but do not freeze it.

The most common side effects of Aplevant 1.5mg injection (0.5ml Each) include nausea, diarrhea, abdominal pain, and loss of appetite. It can also lead to hypoglycemia (low blood sugar level) especially if you are taking other medicines to lower blood sugar. Make sure you know how to recognize and deal with it.

Before using this medicine, talk to your doctor if you have ever had liver or kidney disease, pancreatitis, or stomach problems. Also, tell your doctor if you are taking any other medicines which may affect the way this medicine works. If you are pregnant or breastfeeding, ask your doctor if it is safe to take Aplevant 1.5mg injection (0.5ml Each).

Benefits:

1. Blood Sugar Control: Aplevant 1.5mg injection helps lower blood sugar levels in individuals with type 2 diabetes mellitus, leading to improved glycemic control.
2. Weight Management: Some people may experience weight loss as a beneficial side effect of dulaglutide therapy.
3. Cardiovascular Benefits: Clinical studies have shown that GLP-1 receptor agonists like dulaglutide may provide cardiovascular benefits, such as reducing the risk of major adverse cardiovascular events in patients with established cardiovascular disease.

Side Effects:

1. Gastrointestinal Effects: The most common side effects of dulaglutide include nausea, vomiting, diarrhea, constipation, and abdominal discomfort. These side effects typically improve over time as the body adjusts to the medication.
2. Hypoglycemia: Taking dulaglutide in combination with other antidiabetic medications, particularly insulin or sulfonylureas, may increase the risk of hypoglycemia (low blood sugar). Symptoms of hypoglycemia include sweating, shaking, fast heartbeat, confusion, and dizziness.
3. Injection Site Reactions: Some individuals may experience mild irritation, redness, or itching at the injection site.

Usage Guidelines:

1. Dosage: Aplevant 1.5mg injection is usually administered once weekly via subcutaneous injection. Follow your healthcare provider’s instructions regarding dosage and administration.
2. Administration: Inject the medication subcutaneously into the abdomen, thigh, or upper arm. Rotate injection sites to minimize the risk of injection site reactions.
3. Monitoring: Regularly monitor your blood sugar levels as directed by your healthcare provider. Adjustments to your medication regimen may be necessary to achieve optimal glycemic control.
4. Lifestyle Modifications: Maintain a healthy diet and exercise regimen as recommended by your healthcare provider to complement the effects of dulaglutide therapy.

Drug Interactions:

1. Insulin and Sulfonylureas: Concurrent use of dulaglutide with insulin or sulfonylureas may increase the risk of hypoglycemia. Dose adjustments of these medications may be necessary.
2. Oral Antidiabetic Agents: Some oral antidiabetic agents, such as metformin or thiazolidinediones, may be used concomitantly with dulaglutide to improve glycemic control.
3. Other Medications: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with dulaglutide and affect its effectiveness or increase the risk of side effects.

Always consult your healthcare provider for personalized advice regarding the use of Aplevant 1.5mg injection, especially if you have any pre-existing medical conditions or concerns about its use.

SAFETY ADVICE

Alcohol

UNSAFE

It is unsafe to consume alcohol with Aplevant 1.5mg injection (0.5ml Each).

Pregnancy

CONSULT YOUR DOCTOR

Aplevant 1.5mg injection (0.5ml Each) may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Aplevant 1.5mg injection (0.5ml Each) during breastfeeding is not available. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether Aplevant 1.5mg injection (0.5ml Each) alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney

SAFE IF PRESCRIBED

Aplevant 1.5mg injection(0.5ml Each) is safe to use in patients with kidney disease. No dose adjustment of Aplevant 1.5mg injection (0.5ml Each) is recommended.
However, monitor renal function in patients with renal impairment reporting severe adverse gastrointestinal reactions. Use Aplevant 1.5mg injection (0.5ml Each) with caution in patients with ESRD.

Liver

SAFE IF PRESCRIBED

Aplevant 1.5mg injection (0.5ml Each) is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Aplevant 1.5mg injection (0.5ml Each) may not be needed in these patients. Please consult your doctor.