APIGAT 5MG TABLET 30S

Product Introduction:

Apigat 5mg Tablet is a medication used to prevent blood clots in individuals with certain heart conditions, such as atrial fibrillation, or those who have undergone hip or knee replacement surgery. It belongs to a class of medications known as direct oral anticoagulants (DOACs) or factor Xa inhibitors.

Apigat 5mg Tablet is commonly used in patients with irregular heart rhythm (atrial fibrillation) to prevent clot formation. It also reduces the risk of getting clots in people who have undergone elective knee or hip replacement surgeries. It can be taken with or without food and it is best to take them at the same time each day. You may need to take this medicine for many years, even for life in some cases.

Do not stop taking it or change the dose without guidance from your doctor. It could quickly put you more at risk of having a heart attack, stroke, or thrombosis (formation of a blood clot within a blood vessel). You can reduce your risk of having a blood clot by making changes to your lifestyle, such as not smoking, eating a healthy diet, getting regular exercise, and losing weight if you need to.

The most common side effect of Apigat 5mg Tablet is bleeding more easily than normal, for example, having nosebleeds or bruising. If you experience any symptoms, tell your doctor immediately. Other side effects include hematoma, anemia, and nausea.

Do not take this medicine if you have severe kidney or liver problems, if you are currently bleeding, or if you are taking other medicines to reduce blood clotting. You should not breastfeed while using this medicine. Unlike other anticoagulants, a regular blood test (PT-INR) is not required while taking this medicine.

Benefits:

1. Prevention of Blood Clots: Apigat reduces the risk of blood clots forming in the veins, which can lead to serious conditions such as deep vein thrombosis (DVT) or pulmonary embolism (PE).
2. Stroke Prevention in Atrial Fibrillation: It is also used to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (a heart rhythm disorder).
3. Convenience: Apigat is taken orally, making it convenient for long-term use compared to traditional blood thinners like warfarin that require regular monitoring and dose adjustments.

Side Effects:

1. Bleeding: The most common side effect of Apigat is bleeding. This can range from minor bruising or nosebleeds to more serious bleeding events, such as gastrointestinal bleeding or bleeding in the brain.
2. Allergic Reactions: Rarely, Apigat can cause allergic reactions with symptoms like rash, itching, swelling, severe dizziness, or trouble breathing.

Usage Guidelines:

1. Dosage: The dosage of Apigat is prescribed by your healthcare provider based on your medical condition and response to treatment.
2. Administration: Take Apigat tablets orally with or without food, as directed by your doctor.
3. Duration of Use: Follow your doctor’s instructions carefully regarding the duration of treatment with Apigat. Do not stop taking it suddenly without consulting your doctor, as this may increase the risk of blood clots.
4. Missed Dose: If you miss a dose, take it as soon as you remember on the same day. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Drug Interactions:

1. Other Anticoagulants and Antiplatelet Drugs: Concurrent use with other blood-thinning medications may increase the risk of bleeding.
2. Certain Medications: Drugs that affect liver enzymes (such as ketoconazole, rifampin) or kidney function (such as certain antibiotics) may interact with Apigat.
3. Herbal Supplements: Certain herbal supplements like ginkgo biloba or garlic may increase the risk of bleeding when taken with Apigat.

Precautions:

1. Inform your healthcare provider about all medications you’re taking, including prescription, over-the-counter, and herbal supplements.
2. Report any signs of bleeding (such as unusual bruising, black or bloody stools, or coughing up blood) to your doctor immediately.
3. Avoid activities that may increase the risk of injury or bleeding, such as contact sports or using sharp objects.
4. If you are scheduled for any surgery or dental procedure, inform your healthcare provider that you are taking Apigat.

Always consult your healthcare provider for personalized advice regarding the use of Apigat 5mg Tablet and any adjustments to your treatment plan.

SAFETY ADVICE

Alcohol

CAUTION

Caution is advised when consuming alcohol with Apigat 5mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Apigat 5mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Apigat 5mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

SAFE

Apigat 5mg Tablet does not usually affect your ability to drive.

Kidney

CAUTION

Apigat 5mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Apigat 5mg Tablet may be needed. Please consult your doctor.

Liver

CAUTION

Apigat 5mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Apigat 5mg Tablet may be needed. Please consult your doctor.
However, Apigat 5mg Tablet dose adjustment may not be needed in patients with the mild liver disease.